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Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol Gastrointest Liver Physiol. Dig Dis. 2003 Nov; 112(9):1383-94. 2009 Oct; 297(4):G726-34. 2004 Nov; 40(5):1151-9. 2003 Mar; 37(3):653-64. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. 1988 Jan-Feb; 8(1):176-82. Nat Immunol. Alcohol Clin Exp Res. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. Lehnert M, Uehara T, Bradford BU, Lind H, Zhong Z. Mechanisms of Liver Injury. Hepatology. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. Brenner succeeds Kristiina Vuori, M.D., Ph.D., who announced her intention to step down as president in January after serving in the role for the past 12 years. Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E. The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2. Mol Cell Biol. DNA-mediated gene transfer into adult rat hepatocytes in primary culture. Mol Cell Biol. Hepatology. Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. Allergy. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA. 2006 Jul; 131(1):272-5. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. J Biol Chem. Nuclear factor-kappaB in the liver: friend or foe? J Clin Immunol. 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Blood. PNAS Nexus. Contribution of bone marrow-derived fibrocytes to liver fibrosis. Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. 1998 Oct; 27(3):192-8. Fibrogenesis of parenchymal organs. J Hepatol. 2022 Apr 04. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. 2003 May; 73(1):44-52. 2021 12 09; 12(1):7172. Origin of myofibroblasts in the fibrotic liver in mice. 2005 Mar; 39(3):181-8. Lab Invest. Am J Pathol. Quadruple genetic variants in a sporadic ALS patient. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Immunol Res. J Biol Chem. A method for in vitro DNase I footprinting analysis on supercoiled templates. Mol Ther Nucleic Acids. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. 2005 May; 41(5):1085-95. Trans Am Clin Climatol Assoc. Multiplex short tandem repeat profiling of immortalized hepatic stellate cell line Col-GFP HSC. 2004 May 28; 279(22):23822-9. Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease. 2010 Sep; 139(3):987-98. Gastroenterology. AIDS. La Jolla groups issue letter on city parks master plan. Sam F, Sawyer DB, Xie Z, Chang DL, Ngoy S. Hepatic stellate cells as a target for the treatment of liver fibrosis. 2021 01; 335:113496. 2016 Feb; 43(2):179-87. Proc Am Thorac Soc. 1997 May; 272(5 Pt 1):G943-53. Compr Ther. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. Semin Liver Dis. 1999 Oct; 18(10):751-61. 2009 Sep; 1(8-9):513-24. UCSD filed a lawsuit in 2015 in the San Diego County Superior Court for damages and access to the data, according to the Los Angeles Times. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. 1995 Sep 29; 270(39):22689-92. Liver Int. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J, Forman DT. 1998 May; 27(5):1285-95. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. Studies with human cultured skin fibroblasts. 2006 Aug; 116(8):2058-9. Blood. Bloomer J, Bruzzone C, Zhu L, Scarlett Y, Magness S. Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. 2006 Jul 27; 82(2):241-50. Exp Biol Med (Maywood). Fuji H, Miller G, Nishio T, Koyama Y, Lam K, Zhang V. CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. 1996 Feb; 23(2):379-80. 2022 07; 10(7):e1953. Aliment Pharmacol Ther. 2011 Dec; 17(4):251-7. J Exp Med. People who share similar concepts with this person. Scholarship Fund, Molecular Pathogenesis of Apoptosis in Liver Cells, ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION, GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS, The Southern California Research Center for ALPD and Cirrhosis, Molecular and Cellular Pathogenesis in Alcoholism, MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM, FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS, Molecular Mechanisms by which TNFalpha Modulates Fibrosis. Altman Clinical and Translational Research Institute (ACTRI). The origin of myofibroblasts in liver fibrosis. 2022 08 02; 34(8):1201-1213.e5. Hepatology. Neurogastroenterol Motil. J Natl Cancer Inst. 2004 Jun; 135(6):619-28. 2019 10; 68(10):1884-1892. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. Aliment Pharmacol Ther. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP. What is the potential role of antifibrotic agents for the treatment of liver disease? To a large degree, it was sparked by Dr. David Brenner, UC San Diegos vice chancellor for health sciences. Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. Yilmaz R, Grehl T, Eckrich L, Marschalkowski I, Weishaupt K, Valkadinov I, Simic M. The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury. 2003 May; 37(5):1043-55. Moderate alcohol drinking: effects on the heart and liver. Enomoto N, Yamashina S, Schemmer P, Rivera CA, Bradford BU, Enomoto A. IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Proc Natl Acad Sci U S A. Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers. J Exp Med. Gastroenterology. Hepatology. People in Profiles who have published with this person. Hepatology. Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. Bradham CA, Qian T, Streetz K, Trautwein C. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. 2001 Aug 17; 89(4):351-6. Analysis of the human ferrochelatase promoter in transgenic mice. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Mill?n C. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R. Transcriptional repression of the transforming growth factor (TGF-) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF- signaling in hepatic stellate cells. Gastroenterology. 2016; 7:47. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. Liedtke C, Plmpe J, Kubicka S, Bradham CA, Manns MP. Yang L, Magness ST, Bataller R, Rippe RA. J Stroke Cerebrovasc Dis. J Bioenerg Biomembr. 2006 Sep; 291(3):G456-63. Am J Physiol. Hepatology. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. J Biol Chem. 2022 09; 609(7925):101-108. Derived automatically from this person's publications. J Hepatol. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. Hepatology. Kagnoff MF, Omary MB, de Grandpre LY, Roebuck KA, Richman DD. Regulatory role of the conserved stem-loop structure at the 5' end of collagen alpha1(I) mRNA. Hepatology. J Biol Chem. Int Psychogeriatr. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. 2003 Jul; 39(1):38-46. A simplified method for the preparation of transcriptionally active liver nuclear extracts. Mol Biol Med. We were lucky to get them, said Dr. David Brenner, UCSDs vice chancellor of health sciences. Hepatol Commun. 2021 11; 25(11):2149-2159. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective 2012 Apr; 56(4):965-72. 2000 Dec; 32(6):1255-64. 2015 Apr 06; 212(4):469-80. Data from arrays: an embarrassment of riches. Reversibility of liver fibrosis. Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Hepatology. 1999 09; 277(3):G671-7. Methods Mol Biol. Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. We lose people all of the time. Schnabl B, Hu K, Mhlbauer M, Hellerbrand C, Stefanovic B. Hatano E, Bennett BL, Manning AM, Qian T, Lemasters JJ. Gastroenterology. 2001 Dec; 281(6):G1357-68. Am J Physiol Gastrointest Liver Physiol. J Clin Invest. Hepatology. 2013 Dec; 58(6):1930-40. J Burn Care Rehabil. Hepatology. 2004 Jun; 40(6):942-51. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. 2006 Apr; 290(4):G583-9. Methods for analyzing c-Jun kinase. I. TNF-induced liver injury. 2018 01; 30(1):31-38. 2007 Nov; 2(4):243-4. 1999; 8(3):151-63. 2005; 23(3-4):264-74. Ceramide activates the stress-activated protein kinases. 2012 Nov; 67(11):1357-64. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. 2019 03 29; 10(1):1406. 2001 Jan; 33(1):81-90. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. 2017 Jun 16; 7:314-323. TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. 2014 Apr 29; 63(16):1626-33. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE. Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. 2012 Mar; 27 Suppl 2:65-8. Hepatology. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. J Biol Chem. Moore-Morris T, Guimar?es-Camboa N, Banerjee I, Zambon AC. 2021 05; 134:105933. 1988 Sep-Oct; 8(5):1040-5. Carcinogenesis. Am J Physiol. Hepatology. Harada N, Hatano E, Koizumi N, Nitta T, Yoshida M, Yamamoto N. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells. 2020 12; 72(6):2182-2196. NOX in liver fibrosis. 2009; 44 Suppl 19:1-7. 2010 Jan 12; 107(2):844-9. 1998 Jul; 43(7):1454-64. Insulin-like growth factor-I and epidermal growth factor interact to regulate growth and gene expression in IEC-6 intestinal epithelial cells. Hepatology. Gastroenterology. Cell Mol Gastroenterol Hepatol. Cell Metab. Acceptance Post-Bac. Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Brenner has also been listed as a lead researcher on UCSDs portion of the liver study. 2012 May 22; 109(21):E1369-76. Hepatology. 2009 Jan; 130(1):16-26. Nat Rev Gastroenterol Hepatol. Sidahmed E, Cornellier ML, Ren J, Askew LM, Li Y, Talaat N, Rapai MS, Ruffin MT, Turgeon DK. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS. J Biol Chem. Alcohol Clin Exp Res. 1990 Jan; 85(1):248-55. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. 2002 Sep; 132(3):441-9. 2003 Jan 01; 8:d69-77. Identification of small molecule activators of cryptochrome. Clin Gastroenterol Hepatol. PLoS One. Note that an individual publication can be assigned to more than one field. Stroke. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. Mol Genet Genomic Med. 1991 Oct; 14(4 Pt 1):740-2. Hepatic porphyrias. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. 1992 Sep 04; 70(5):777-89. Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. 1998 Aug; 115(2):443-51. Clin Gastroenterol Hepatol. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. 2021; 16(12):e0260721. Am J Physiol. 1984; 49:151-60. J Clin Invest. 1994 Sep; 17(3):410-2. Dig Liver Dis. J Surg Res. Front Physiol. Gut. 2014 Jul; 124(7):2921-34. He will assume his new role effective September 14. Type I collagen gene regulation and the molecular pathogenesis of cirrhosis. Enomoto N, Schemmer P, Ikejima K, Takei Y, Sato N. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. 1991 Mar; 5(3):275-81. The role of Smad3 in mediating mouse hepatic stellate cell activation. J Lab Clin Med. Am J Physiol Gastrointest Liver Physiol. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R. JNK mediates hepatic ischemia reperfusion injury. 2007 Jun; 132(7):2601-4. Alcohol Clin Exp Res. Copyright The Regents of the University of California, Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. 2022 07 05; 34(7):978-990.e4. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. 2015 Sep; 39 Suppl 1:S75-9. MELD and the practicing gastroenterologist. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. Clin Immunol. Vuori will 2003 Mar; 37(3):493-503. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. Uzawa K, Grzesik WJ, Nishiura T, Kuznetsov SA, Robey PG. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA. 2002 Oct; 4(5):769-81. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Hepatology. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER. Am J Clin Nutr. 2000; 35 Suppl 12:80-3. Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ. Brain Commun. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. 2007 Jun; 22 Suppl 1:S73-8. 2012 Aug 31; 337(6098):1094-7. He did not respond to inewsource s interview request. Nat Rev Gastroenterol Hepatol. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. J Biol Chem. 2011 Mar 11; 286(10):8609-8619. 2001 Apr 10; 103(14):1920-7. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. 2017 10 10; 114(41):10808-10809. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. Hepatology. Hepatology. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. 1998 Sep; 13 Suppl:S93-5. PLoS One. 2005 Feb; 115(2):209-18. 2012 Dec; 56(6):2316-27. Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA. medRxiv. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. Gut. 2014 Jul 21; 5:4451. Am J Hum Genet. We lose people all of IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. This graph shows the total number of publications by year. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Arch Biochem Biophys. The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. 2008 Mar; 23 Suppl 1:S98-103. A logical approach to the patient with jaundice. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. 1999 Mar; 15(2):103-7. Am J Physiol Cell Physiol. 1995; (33):212-4. 2011 Apr; 300(4):G516-25. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Mitogens and hepatocyte growth control in vivo and in vitro. Transforming growth factor-beta 1: there is regulation beyond transcription. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. Methods Enzymol. Estriol sensitizes rat Kupffer cells via gut-derived endotoxin. Antioxid Redox Signal. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. 2000 Jan; 48(1):39-44. Hepatology. 2021; 8:790032. Biology (Basel). 2018 01; 53(1):6-17. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. Liver Transpl. Tacke F, Gbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C. The genetics of nonalcoholic fatty liver disease. Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. Yale J Biol Med. 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